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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name HIF-1α siRNA
ncRNA Category siRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line Y79
Methods siRNA transfection, RT-PCR, Western blot
Expression pattern associated
Functional description Knockdown of HIF-1α resulted in a significant decrease in proliferation thereby demonstrating that HIF-1α is involved in promoting survival and proliferation in retinoblastoma cells.
PubMed ID 24338218
Year 2014
Title Hypoxia-inducible factor-1α and its role in the proliferation of retinoblastoma cells.
Drug-related ncRNA NO

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